Scientist Product Sciences

Profile

Bristol-Myers Squibb is a global Biopharma company committed to a single mission: to discover, develop, and deliver innovative medicines focused on helping millions of patients around the world in disease areas such as oncology, cardiovascular, immunoscience and fibrosis.

Join us and make a difference. We hire the best people and provide them with a work environment that places a premium on diversity, integrity, collaboration and personal development. Through a culture of inclusion, we create a better, more productive work environment. We believe that the diverse experiences and perspectives of all our employees help to drive innovation and transformative business results.

PURPOSE AND SCOPE OF POSITION:

The Cell Therapy Product Sciences department is seeking a Scientist to support the development of early stage CAR T and engineered TCR cell products. The Product Sciences Team is responsible for developing and executing mechanism of action and characterization studies to support the development of gene-engineered T cell therapies. The primary focus of the Scientist - Product Sciences role will be to build CAR T cell product and process understanding in support of pipeline projects. Successful candidates will have a strong foundation in human T cell biology and experience with implementation and optimization of a broad range of in vitro cell-based and molecular assays. This role is highly collaborative and requires a demonstrated ability to lead cross-functional teams and independently design and execute studies to meet project goals.

REQUIRED COMPETENCIES: Knowledge, Skills, and Abilities:

Education:

BS and 10 years/MS and 8 years/ PhD and 2 years in Biology, Cell Biology, Immunology, or relevant discipline

Experience

Qualifications and Education Requirements

Ability to work in a high paced team environment, meet deadlines, and prioritize work on multiple projects.

Excellent interpersonal, written and verbal communication skills, and attention to detail

Expertise in human T cell biology and in vitro modulation of T cell differentiation and function with small molecules and/or biologics.

Expertise in multi-parameter flow cytometry and in vitro T cell functional assays.

Expertise in the application of genome-wide expression analytical platforms.

Demonstrated independence in experimental design, data analysis, interpretation, and presentation.

Proven ability to work in a high paced team environment, meet deadlines, & prioritize work on multiple projects.

Strong verbal and written skills.

Preferred Qualifications

Experience with standard and next generation analytical platforms for the characterization of T cell phenotype, differentiation, and function.

Experience with genome-wide expression platform implementation and analysis, microarray, NanoString, RNA-seq, or other.

Understanding of cell signaling pathways involved in memory T cell differentiation.

Demonstrated experience in leadership roles providing scientific mentorship.

Experience authoring regulatory documents, including IND and BLA filings.

Track record of successful internal and external scientific collaborations.

DUTIES AND RESPONSIBILITIES:

Design and deploy in-depth characterization of gene engineered T cells using flow cytometry, genome-wide expression analysis, metabolic profiling, and additional cutting edge analytical techniques.

Participate and lead cross-functional teams to support the development of gene engineered T cell therapeutic platforms.

Identification and prioritization of novel analytical approaches for interrogating gene engineered T cell function.

Develop and maintain relationships with external collaborators and service providers.

Serve as T cell biology subject matter expert in multidisciplinary team setting, that includes non-clinical, clinical, regulatory, and CMC functions.

Perform and manage instrument and method troubleshooting

Author, review, and approve technical documents, including methods, protocols, reports, and SOPs

Learn and apply ICH/FDA/EMEA guidance and current thinking.

WORKING CONDITIONS (US Only):

Office and laboratory environments with a mix of natural and LED lighting with low level of background noise. Required computer and conferencing hardware are provided. 40% seated at a desk with ergonomic and sit/stand desks and 60% time in laboratory or meetings.

Local, national, and international travel up to 5%

This job description is intended to describe the general nature and level of work being performed by the person assigned to this position. The primary duties and responsibilities are intended to describe those functions that are essential to the performance of this job.

This job description does not state or imply that the above are the only duties and responsibilities assigned to this position. There are other duties and responsibilities that are considered incidental or secondary to the overall purpose of this job. Employees holding this position will be required to perform any other job-related duties as requested by management.

Bristol-Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees the resources to pursue their goals, both at work and in their personal lives.

Bristol-Myers Squibb is an equal opportunity employer. Qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or protected veteran status.

Company info

Bristol-Myers Squibb Company
Website : http://www.bms.com